Yi-Ming Arthur Chen Selected Research

Glycine N-Methyltransferase (Glycine Sarcosine N-Methyltransferase)

1/2019	Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma.
1/2018	MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma.
1/2018	AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage.
10/2016	Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
5/2016	Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma.
3/2015	Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis.
3/2014	Role of glycine N-methyltransferase in experimental ulcerative colitis.
1/2014	Genetic polymorphisms of the glycine N-methyltransferase and prostate cancer risk in the health professionals follow-up study.
7/2012	Deficiency of glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice.
5/2012	Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis.

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Yi-Ming Arthur Chen Research Topics

Disease

16	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 02/2003
16	Infections 02/2020 - 05/2004
15	Neoplasms (Cancer) 02/2020 - 02/2003
8	Liver Neoplasms (Liver Cancer) 01/2021 - 05/2004
6	Acquired Immunodeficiency Syndrome (AIDS) 01/2020 - 08/2009
5	Carcinogenesis 01/2019 - 05/2004
4	Hypermethioninemia 10/2016 - 11/2007
4	Prostatic Neoplasms (Prostate Cancer) 01/2014 - 03/2007
4	Severe Acute Respiratory Syndrome 10/2011 - 11/2006
3	COVID-19 07/2021 - 01/2021
3	Liver Cirrhosis (Hepatic Cirrhosis) 02/2020 - 05/2009
3	Virus Diseases (Viral Diseases) 01/2019 - 08/2009
3	Human Influenza (Influenza) 08/2016 - 05/2009
3	Chronic Hepatitis (Chronic Active Hepatitis) 05/2012 - 11/2007
2	Liver Diseases (Liver Disease) 02/2020 - 07/2012
2	Hepatitis 01/2019 - 03/2014
2	Hepatitis B 01/2019 - 01/2016
2	HIV Infections (HIV Infection) 01/2016 - 07/2011
2	Atherosclerosis 03/2014 - 07/2012
2	Inflammation (Inflammations) 07/2012 - 05/2009
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2021
1	Neoplasm Metastasis (Metastasis) 02/2020
1	Fibrosis (Cirrhosis) 02/2020
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 08/2019
1	Opportunistic Infections (Opportunistic Infection) 01/2019
1	Gastritis 01/2019
1	Experimental Liver Neoplasms 01/2018
1	Autoimmune Diseases (Autoimmune Disease) 01/2017
1	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease) 01/2017
1	Ankylosing Spondylitis 01/2017
1	Uveitis 01/2017
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2017
1	Polymyositis 01/2017
1	Thyroiditis 01/2017
1	Rheumatoid Arthritis 01/2017
1	Insulin Resistance 10/2016

Drug/Important Bio-Agent (IBA)

21	Glycine N-Methyltransferase (Glycine Sarcosine N-Methyltransferase)IBA 01/2019 - 02/2003
11	Proteins (Proteins, Gene)FDA Link 03/2021 - 02/2003
5	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 02/2003
4	Sarcosine (Methylglycine)IBA 01/2021 - 08/2012
3	TransferasesIBA 03/2021 - 01/2019
3	EnzymesIBA 01/2019 - 02/2006
3	Pharmaceutical PreparationsIBA 01/2018 - 07/2011
3	Biomarkers (Surrogate Marker)IBA 01/2017 - 06/2015
3	Neutralizing AntibodiesIBA 08/2016 - 02/2006
3	CholesterolIBA 07/2012 - 11/2007
3	DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN)IBA 08/2011 - 11/2006
3	VaccinesIBA 12/2010 - 11/2006
2	CarcinogensIBA 01/2021 - 04/2010
2	Insulin (Novolin)FDA Link 08/2019 - 10/2016
2	Prostaglandins GIBA 01/2019 - 05/2016
2	Messenger RNA (mRNA)IBA 01/2018 - 05/2016
2	Illicit Drugs (Recreational Drugs)IBA 01/2018 - 01/2015
2	LubricantsIBA 01/2018 - 01/2015
2	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2018 - 05/2009
2	Hemagglutinins (Hemagglutinin)IBA 08/2016 - 08/2009
2	AflatoxinsIBA 05/2016 - 02/2011
2	SolutionsIBA 01/2015 - 04/2010
2	Monoclonal AntibodiesIBA 08/2014 - 09/2008
2	NucleotidesIBA 08/2007 - 05/2007
2	Benzo(a)pyreneIBA 07/2006 - 05/2004
2	Complementary DNA (cDNA)IBA 07/2006 - 05/2004
1	Fluorine-18IBA 07/2021
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 07/2021
1	SodiumIBA 03/2021
1	limbic system-associated membrane proteinIBA 03/2021
1	Superoxide Dismutase-1IBA 03/2021
1	GABA Plasma Membrane Transport ProteinsIBA 03/2021
1	ChloridesIBA 03/2021
1	Excitatory Amino Acid Transporter 2IBA 03/2021
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 03/2021
1	rho Guanine Nucleotide Dissociation Inhibitor alphaIBA 03/2021
1	Serum AlbuminIBA 03/2021
1	Antiviral Agents (Antivirals)IBA 02/2021
1	Chloroquine (Aralen)FDA LinkGeneric 02/2021
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 02/2021
1	Bone Morphogenetic Protein 5IBA 02/2020
1	AntigensIBA 02/2020
1	hepatitis B virus X proteinIBA 02/2020
1	Long Noncoding RNAIBA 01/2020
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2019
1	XenobioticsIBA 01/2019
1	hepatoma-derived growth factorIBA 01/2019
1	Epirubicin (Ellence)FDA LinkGeneric 01/2018
1	Betulinic AcidIBA 01/2018
1	Celecoxib (Celebrex)FDA Link 01/2018
1	abacavir (Ziagen)FDA Link 01/2018
1	VimentinIBA 01/2017
1	Cadherins (E-Cadherin)IBA 01/2017
1	Triglycerides (Triacylglycerol)IBA 10/2016
1	Ribosomal Proteins (Ribosomal Protein)IBA 10/2016
1	LipidsIBA 10/2016
1	Glucose (Dextrose)FDA LinkGeneric 10/2016

Therapy/Procedure

6	Therapeutics 01/2021 - 08/2009
2	Highly Active Antiretroviral Therapy (HAART) 01/2019 - 01/2017
1	Aftercare (After-Treatment) 02/2021
1	Personal Protective Equipment 01/2021
1	Condoms (Condom) 01/2018
1	Drug Therapy (Chemotherapy) 01/2018